Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline
Paraish S Misra, Stephen G Szeto, Adriana Krizova, Richard E Gilbert, Darren A Yuen
BMC Nephrology | BMC | Published : 2020
BACKGROUND: While histopathologic changes correlate with functional impairment in cross-sectional studies of diabetic nephropathy (DN), whether these findings predict future rate of kidney function loss remains uncertain. We thus sought to examine the relationship between kidney histopathology, incidence of end-stage kidney disease (ESKD), and rate of estimated glomerular filtration rate (eGFR) loss in DN. METHODS: In this longitudinal cohort study, we studied 50 adults diagnosed with biopsy-proven DN. We analyzed the histopathologic parameters of each patient's kidney biopsy, as defined by the Renal Pathology Society classification system for DN, and tracked all available eGFR measurements ..View full abstract
This study was supported by a Banting and Best Diabetes Centre Transformational Team Grant. The funding body had no role in study design, data collection, analysis, and interpretation, and manuscript writing. PSM was supported by a Kidney Foundation of Canada KRESCENT post-doctoral fellowship. DAY was supported by a CIHR New Investigator Award, an Early Researcher Award from the Ontario Ministry of Research and Innovation, and a KRESCENT New Investigator/Canadian Diabetes Association Clinician Scientist award.