Journal article

Association of Body Mass Index in Youth With Adult Cardiometabolic Risk

Feitong Wu, Markus Juonala, Matthew A Sabin, Marie-Jeanne Buscot, Katja Pahkala, Kylie J Smith, Nina Hutri-Kahonen, Mika Kahonen, Tomi P Laitinen, Jorma SA Viikari, Olli T Raitakari, Costan G Magnussen

Journal of the American Heart Association | WILEY | Published : 2020

Abstract

Background Whether long-term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity from youth to adulthood is associated with adult cardiometabolic risk. Methods and Results A population-based cohort study was performed of 1268 youths, aged 3 to 18 years, with follow-ups at 3, 6, 9, 12, 21, 27, and 31 years. Duration of overweight or obesity over 31-year follow-up was calculated. Adulthood outcomes included type 2 diabetes mellitus, impaired fasting glucose, high insulin levels, high carotid intima-media thickness, hypertension, low high-density lipoprotein ch..

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Grants

Awarded by Academy of Finland


Awarded by Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere, and Turku University Hospitals


Awarded by EU


Awarded by European Research Council


Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council Early Career Fellowship


Awarded by National Heart Foundation of Australia Future Leader Fellowship


Funding Acknowledgements

Y.F.S. has been financially supported by the Academy of Finland: grants 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere, and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; and EU Horizon 2020 (grant 755320 for TAXINOMISIS); and European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation. This study was supported by a grant from the National Health and Medical Research Council Project Grant (APP1098369). F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.J.S. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1072516). C.G.M. was supported by a National Heart Foundation of Australia Future Leader Fellowship (100849). They did not have any role in the study concept, design, data analysis, writing of the article, or submission of the article for publication. The researchers are totally independent of the funders.