Journal article
Association of Body Mass Index in Youth With Adult Cardiometabolic Risk
Feitong Wu, Markus Juonala, Matthew A Sabin, Marie-Jeanne Buscot, Katja Pahkala, Kylie J Smith, Nina Hutri-Kahonen, Mika Kahonen, Tomi P Laitinen, Jorma SA Viikari, Olli T Raitakari, Costan G Magnussen
Journal of the American Heart Association | WILEY | Published : 2020
Abstract
Background Whether long-term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity from youth to adulthood is associated with adult cardiometabolic risk. Methods and Results A population-based cohort study was performed of 1268 youths, aged 3 to 18 years, with follow-ups at 3, 6, 9, 12, 21, 27, and 31 years. Duration of overweight or obesity over 31-year follow-up was calculated. Adulthood outcomes included type 2 diabetes mellitus, impaired fasting glucose, high insulin levels, high carotid intima-media thickness, hypertension, low high-density lipoprotein ch..
View full abstractGrants
Awarded by Academy of Finland
Awarded by Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere, and Turku University Hospitals
Awarded by EU
Awarded by European Research Council
Awarded by National Health and Medical Research Council
Awarded by National Health and Medical Research Council Early Career Fellowship
Awarded by National Heart Foundation of Australia Future Leader Fellowship
Funding Acknowledgements
Y.F.S. has been financially supported by the Academy of Finland: grants 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere, and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; and EU Horizon 2020 (grant 755320 for TAXINOMISIS); and European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation. This study was supported by a grant from the National Health and Medical Research Council Project Grant (APP1098369). F.W. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661). K.J.S. is supported by a National Health and Medical Research Council Early Career Fellowship (APP1072516). C.G.M. was supported by a National Heart Foundation of Australia Future Leader Fellowship (100849). They did not have any role in the study concept, design, data analysis, writing of the article, or submission of the article for publication. The researchers are totally independent of the funders.