Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases.
Evangelia Sarandi, Maria Thanasoula, Chrisanthi Anamaterou, Evangelos Papakonstantinou, Francesco Geraci, Maria Michelle Papamichael, Catherine Itsiopoulos, Dimitris Tsoukalas
Advances in Clinical Chemistry | Advances in Clinical Chemistry | Published : 2021
Metabolomics is a powerful tool of omics that permits the simultaneous identification of metabolic perturbations in several autoimmune and chronic diseases. Several parameters can affect a metabolic profile, from the population characteristics to the selection of the analytical method. In the current chapter, we summarize the main analytical methods and results of the metabolic profiling of fatty and organic acids performed in human metabolomic studies for asthma, COPD, psoriasis and Hashimoto's thyroiditis. We discuss the most significant metabolic alterations associated with these diseases, after comparison of either a single patient's group with healthy controls or several patient's subgr..View full abstract