Journal article

Conductive and protein resistant polypyrrole films for dexamethasone delivery

B Zhang, PJ Molino, AR Harris, Z Yue, SE Moulton, GG Wallace

Journal of Materials Chemistry B | ROYAL SOC CHEMISTRY | Published : 2016

Abstract

The development of inherently conducting polymers as controllable/programmable drug delivery systems has attracted significant interest in medical bionics, and the interfacial properties of the polymers, in particular, protein adsorption characteristics, is integral to the stability of the overall performance. Herein we report a hybrid conducting system based on polypyrrole doped with an anti-inflammatory prodrug, dexamethasone phosphate (DexP), upon which post-surface modification was conducted to render the polymer more biostable. We firstly investigated the influence of the current density and DexP concentration on the physiochemical properties and surface characteristics of the resulting..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by ARC under the Australian Laureate Fellowship scheme


Funding Acknowledgements

The authors acknowledge the financial support of the HEARing Cooperative Research Centre, established and supported under the Cooperative Research Centres Program-Business Australia. The authors also thank the Australian Research Council (ARC) for continuing financial support (CE140100012). GGW is grateful to the ARC for support under the Australian Laureate Fellowship scheme (FL10100196). The authors acknowledge the support of the Australian National Fabrication Facility (ANFF). BZ would like to thank A/Prof Robert Cowan and Dr Carrie Newbold from the HEARing CRC for their advice.