Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-beta Plaques
Asif Noor, David J Hayne, SinChun Lim, Jessica K Van Zuylekom, Carleen Cullinane, Peter D Roselt, Catriona A McLean, Jonathan M White, Paul S Donnelly
INORGANIC CHEMISTRY | AMER CHEMICAL SOC | Published : 2020
Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imaging with tracers radiolabeled with positron-emitting radionuclides that bind to amyloid-β plaques can assist in the diagnosis of Alzheimer's disease. With the goal of designing new imaging agents radiolabeled with positron-emitting copper-64 radionuclides that bind to amyloid-β plaques, a family of bis(thiosemicarbazone) ligands with appended substituted stilbenyl functional groups has been prepared. The ligands form charge-neutral and stable complexes with copper(II). The new ligands can be radiolabeled with copper-64 at room temperature. Two lead complexes were de..View full abstract
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Awarded by Australian Research Council
The Australian Research Council is acknowledged for financial support (DP160100288, LP150100656).