Journal article

CD8( ) tumor-infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival

Rosemary Millen, Shona Hendry, Vignesh Narasimhan, Rebecca Abbott, Matthew Croxford, Peter Gibbs, Jeanne Tie, Hui-Li Wong, Ian Jones, Suzanne Kosmider, David Byrne, John Zalcberg, Stephen Fox, Jayesh Desai, Kumar Visvanathan, Robert G Ramsay, Ben Tran

CLINICAL & TRANSLATIONAL IMMUNOLOGY | WILEY | Published : 2020

Abstract

Objectives: Tumor-infiltrating lymphocytes (TIL), particularly CD8+ TILs in patients with colorectal cancer (CRC), are highly prognostic in the early-disease stages (I-II). In metastatic disease (stage IV; mCRC), their influence is less well defined. It has presumably failed to contain tumor cells to the primary site; however, is this evident? We explored the prognostic impact of TILs at the primary site in patients who presented de novo with mCRC. Methods: Treatment-naïve patients (109) with mCRC were assessed for CD8+ TILs and PD-L1 expression. Microsatellite instability (MSI) was evaluated by IHC for PMS2 and MSH6 proteins and/or by PCR using the Bethesda panel. Results: Microsatellite in..

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