Journal article

Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial

Marian Knight, Virginia Chiocchia, Christopher Partlett, Oliver Rivero-Arias, Xinyang Hua, Kim Hinshaw, Derek Tuffnell, Louise Linsell, Edmund Juszczak, Marian Knight, Helen Enderby, Derek Tuffnell, Kim Hinshaw, Ranee Thakar, Abdul H Sultan, Julia Sanders, Dharmintra Pasupathy, Philip Moore, James Gray, Oliver Rivero-Arias Show all



BACKGROUND: Risk factors for maternal infection are clearly recognised, including caesarean section and operative vaginal birth. Antibiotic prophylaxis at caesarean section is widely recommended because there is clear systematic review evidence that it reduces incidence of maternal infection. Current WHO guidelines do not recommend routine antibiotic prophylaxis for women undergoing operative vaginal birth because of insufficient evidence of effectiveness. We aimed to investigate whether antibiotic prophylaxis prevented maternal infection after operative vaginal birth. METHODS: In a blinded, randomised controlled trial done at 27 UK obstetric units, women (aged ≥16 years) were allocated to r..

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