Journal article

Coronary artery calcium scoring in cardiovascular risk assessment of people with family histories of early onset coronary artery disease

Prasanna Venkataraman, Tony Stanton, Danny Liew, Huynh Quan, Stephen J Nicholls, Geoffrey K Mitchell, Gerald F Watts, Andrew Maxwell Tonkin, Thomas H Marwick



OBJECTIVES: To assess the predictive value of the Australian absolute cardiovascular disease risk (ACVDR) calculator and other assessment tools for identifying Australians with family histories of early onset coronary artery disease (CAD) who have coronary artery calcification. DESIGN, SETTING, PARTICIPANTS: People without known CAD were recruited at seven Australian hospitals, October 2016 - January 2019. Participants were aged 40-70 years, had a family history of early onset CAD, and a 5-year ACVDR of 2-15%. MAIN OUTCOME MEASURES: CT coronary artery calcium score greater than zero (any coronary calcification) or greater than 100 (calcification warranting lipid therapy). RESULTS: 1059 parti..

View full abstract


Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by a project grant (GRT1080582) and Postgraduate Scholarship for Prasanna Venkataraman from the National Health and Medical Research Council, and by the Wishlist Sunshine Coast Health Foundation. We acknowledge the commitment of our volunteers and the tireless work of the study coordinators, Kristyn Whitmore (Hobart), Jackie Ryan (Perth), Jasmine Pritchard, Joanne Harris and Louise Brown (Melbourne), Sara McLennan (Brisbane), and Jessica Phillips and Kristen Fragnito (Adelaide).