Journal article

Estimated insulin sensitivity in Type 1 diabetes adults using clinical and research biomarkers

Andrzej S Januszewski, Nirupa Sachithanandan, Glenn Ward, Connie S Karschimkus, David N O'Neal, Alicia J Jenkins

Diabetes Research and Clinical Practice | ELSEVIER IRELAND LTD | Published : 2020

Abstract

AIMS: Insulin resistance in people with type 1 diabetes (T1D) is associated with increased risk of chronic complications and death. The gold standard to quantify insulin sensitivity, a euglycaemic hyperinsulinaemic clamp, is not applicable to clinical practice. We have employed clamp studies to develop a panel of formulae to estimate insulin sensitivity in adults with T1D for use in clinical practice and trials. METHODS: Clamps were conducted in 28 adults with T1D, who were also characterised with 38 clinical and research biomarkers. Exhaustive search analysis was used to derive equations correlating with clamp-quantified glucose disposal rate (GDR), GDR/plasma insulin (M/I) and log10M/I. RE..

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Grants

Funding Acknowledgements

NS was supported by a NHMRC Postgraduate scholarship and a St. Vincent's Institute scholarship. AJJ was supported by a National Health and Medical Research Council Practitioner Fellowship and was a Sydney Medical Foundation Fellow. Funding was provided by a Royal Australian College of Physicians-JDRF Australia Grant and the St. Vincent's Hospital Research Foundation. Equipment grants were provided by the Rebecca Cooper Foundation and the University of Melbourne.