Journal article

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8( )T cells

Sneha Sant, Sergio M Quinones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi HO Nguyen, Katherine Kedzierska

PLOS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity against human influenza viruses. Several universally-conserved CD8+ T-cell specificities that elicit prominent responses against human influenza A viruses (IAVs) have been identified. These include HLA-A*02:01-M158-66 (A2/M158), HLA-A*03:01-NP265-273, HLA-B*08:01-NP225-233, HLA-B*18:01-NP219-226, HLA-B*27:05-NP383-391 and HLA-B*57:01-NP199-207. The immunodominance hierarchies across these universal CD8+ T-cell epitopes were however unknown. ..

View full abstract

Grants

Awarded by NHMRC


Awarded by European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant


Funding Acknowledgements

This work was supported by an NHMRC Program Grant (1071916) to KK. KK is an NHMRC Senior Research Level B Fellow. SS was supported by the Victoria-India Doctoral Scholarship (VIDS) and Melbourne International Fee Remission Scholarship (MIFRS). EJG Is supported by an NHMRC CJ Martin Fellowship. C.E.S. has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 792532 and University of Melbourne McKenzie Fellowship laboratory support. SG is supported by an NHMRC Senior Research Fellowship. JR was supported by an ARC Laureate fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.