Interpreting MAIA Microperimetry Using Age- and Retinal Loci-Specific Reference Thresholds
Jason Charng, Paul G Sanfilippo, Mary S Attia, Monika Dolliver, Sukanya Arunachalam, Avenell L Chew, Evan N Wong, David A Mackey, Fred K Chen
Translational Vision Science and Technology | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2020
Purpose: Macular Integrity Assessment (MAIA) microperimetry is used widely in clinical trials and routine practice to assess paracentral scotoma. Current interpretation of MAIA is based on an assumed uniform 25 decibel (dB) cutoff for normal function irrespective of subject age and retinal location. We examined this convention by establishing an age- and loci-specific reference in healthy eyes and comparing this to the <25 dB cutoff. Methods: Retrospective MAIA results from healthy eyes were analyzed for prevalence of loci with <25 dB. At each locus, a new reference cutoff was derived from quantile regression of sensitivity against age at the 2.5th percentile. Two clinical cases of serial MA..View full abstract
Awarded by National Health and Medical Research Council (Centre of Research Excellence)
Awarded by National Health and Medical Research Council
FKC receives funding from the National Health and Medical Research Council (Centre of Research Excellence Grant 116360, Fellowships 1054712, 1142962). DAM is supported by a National Health and Medical Research Council practitioner fellowship (1154518).