Journal article

The Type IX Secretion System: Advances in Structure, Function and Organisation

Dhana G Gorasia, Paul D Veith, Eric C Reynolds

MICROORGANISMS | MDPI | Published : 2020

Abstract

The type IX secretion system (T9SS) is specific to the Bacteroidetes phylum. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilises the T9SS to transport many proteins-including its gingipain virulence factors-across the outer membrane and attach them to the cell surface. Additionally, the T9SS is also required for gliding motility in motile organisms, such as Flavobacterium johnsoniae. At least nineteen proteins have been identified as components of the T9SS, including the three transcription regulators, PorX, PorY and SigP. Although the components are known, the overall organisation and the molecular mechanism of how the T9SS operates is largely unknown. This review focu..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Australian Government Department of Industry, Innovation and Science Grant


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council grant ID 1123866 and the Australian Government Department of Industry, Innovation and Science Grant ID 20080108.