Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves beta-cell function in streptozotocin-nicotinamide induced diabetic rats
Aditya Arya, Mazen M Jamil Al-Obaidi, Rustini Binti Karim, Hairin Taha, Ataul Karim Khan, Nayiar Shahid, Abu Sadat Sayem, Chung Yeng Looi, Mohd Rais Mustafa, Mustafa Ali Mohd, Hapipah Mohd Ali
JOURNAL OF ETHNOPHARMACOLOGY | ELSEVIER IRELAND LTD | Published : 2015
ETHNOPHARMACOLOGICAL RELEVANCE: The art of Ayurveda and the traditional healing system in India have reflected the ethnomedicinal importance of the plant Woodfordia fruticosa Kurtz, which demonstrates its vast usage in the Ayurvedic preparations as well as in the management of diabetes by the traditional healers. AIMS OF STUDY: The study aimed to ascertain the antidiabetic potential of W. fruticosa flower methanolic extract (WF) on Streptozotocin (STZ)-nicotinamide-induced diabetic rat model. MATERIALS AND METHODS: Diabetes was induced in Sprague Dawley (SD) rats by STZ-nicotinamide and thereafter diabetic rats were treated with three different doses of WF (100, 200 and 400mg/kg body weight)..View full abstract
Awarded by High Impact Research Grant (UM-MOHE)
Awarded by Fundamental Research Grant (FRGS) from Ministry of Higher Education; Malaysia
Awarded by University of Malaya Research Grant (UMRG)
The accomplishment of this research was made possible by the support of High Impact Research Grant (UM-MOHE UM.C/625/1/HIR/MOHE/09) and the Fundamental Research Grant (FRGS): FP021-2014A from the Ministry of Higher Education; Malaysia and the University of Malaya Research Grant (UMRG Grant no: RP001D-13BIO).