NAP (davunetide) protects primary hippocampus culture by modulating expression profile of antioxidant genes during limiting oxygen conditions
A Arya, R Meena, NK Sethy, M Das, M Sharma, K Bhargava
FREE RADICAL RESEARCH | TAYLOR & FRANCIS LTD | Published : 2015
Hypoxia is a well-known threat to neuronal cells and triggers the pathophysiological syndromes in extreme environments such as high altitudes and traumatic conditions such as stroke. Among several prophylactic molecules proven suitable for ameliorating free radical damage, NAP (an octapeptide with initial amino acids: asparagine/N, alanine/A, and proline/P) can be considered superlative, primarily due to its high permeability into brain through blood-brain barrier and observed activity at femtomolar concentrations. Several mechanisms of action of NAP have been hypothesized for its protective role during hypoxia, yet any distinct mechanism is unknown. Oxidative stress is advocated as the lead..View full abstract
The authors would like to acknowledge Ms. Ankita Yadava and Ms. Anamika Gangwar for support in preparation of this manuscript. Aditya Arya is a recipient of Senior Research Fellowship (SRF) from Council of Scientific and Industrial Research (CSIR), Government of India.