Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
Abu Sadat Md Sayem, Aditya Arya, Hamed Karimian, Narendiran Krishnasamy, Ameya Ashok Hasamnis, Chowdhury Faiz Hossain
Molecules | MDPI | Published : 2018
Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise primarily due to consistent high blood glucose levels. Insulin and glucagon help to maintain the homeostasis of glucose and lipids through signaling cascades. Pancreatic hormones stimulate translocation of the glucose transporter isoform 4 (GLUT4) from an intracellular location to the cell surface and facilitate the rapid insulin-dependent storage of glucose in muscle and fat cells. Malfunction in g..View full abstract
This review is a part of Taylor's University Flagship Research under the theme "Ageing and Quality of Life" (Project No: TUFR/2017/002/01). We would like to thank P.T. Thomas, Executive Dean of the Faculty of Health and Medical Sciences for his encouragement and support.