Journal article

Evaluation of Palm Oil-Based Paracetamol Suppositories by Differential Scanning Calorimetry

Mohamed Ibrahim Noordin, Chung Lip Yong, Ilyana Mofat, Zainorwan Zainuddin, Aditya Arya, Shaik Nyamathulla

Tropical Journal of Pharmaceutical Research | PHARMACOTHERAPY GROUP | Published : 2014


Purpose: To use differential scanning calorimetry (DSC) to predict the liquefaction time and dissolution profile of some commercial paracetamol suppositories as well as paracetamol suppositories formulated with palm oil base. Methods: The suppository base was prepared by mixing hydrogenated palm oil and palm kernel stearin in a ratio of 8:2. Three commercial paracetamol suppositories (A, B, and C) were purchased, while product D, paracetamol suppository was formulated with suppository base using the double casting method. In-vitro drug release from suppositories was determined using DSC and the effect of liquefaction on drug release was studied. The relationship between suppository melting a..

View full abstract

University of Melbourne Researchers