Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus
Siti Hajar Adam, Nelli Giribabu, Normadiah Kassim, Kilari Eswar Kumar, Manuri Brahmayya, Aditya Arya, Naguib Salleh
Biomedicine & Pharmacotherapy | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2016
INTRODUCTION: Protective effects of Vitis Vinifera seed aqueous extract (VVSAE) against pancreatic dysfunctions and elevation of oxidative stress, inflammation and apoptosis in the pancreas in diabetes were investigated. Histopathological changes in the pancreas were examined under light microscope. METHODS: Blood and pancreas were collected from adult male diabetic rats receiving 28days treatment with VVSAE orally. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), insulin and lipid profile levels and activity levels of anti-oxidative enzymes (superoxide dismutase-SOD, catalase-CAT and glutathione peroxidase-GPx) in the pancreas were determined by biochemical assays. Histopathologica..View full abstract
Awarded by University of Malaya, Kuala Lumpur, Malaysia
This study was funded by University Malaya Research Grant (UMRG) (No: RP011/13HTM) and Postgraduate Research Grant (PPP) (No: PG217-2015A), University of Malaya, Kuala Lumpur, Malaysia.