Rhinacanthin C ameliorates hyperglycaemia, hyperlipidemia and pancreatic destruction in streptozotocin-nicotinamide induced adult male diabetic rats
Siti Hajar Adam, Nelli Giribabu, Pasupuleti Visweswara Rao, Abu Sadat Md Sayem, Aditya Arya, Pharkphoom Panichayupakaranant, Praveen Kumar Korla, Naguib Salleh
European Journal of Pharmacology | ELSEVIER SCIENCE BV | Published : 2016
Effect of Rhinacanthin C on hyperglycaemia, hyperlipidemia and pancreatic dysfunction in diabetes was investigated. In-vitro effect of Rhinacanthin C on glucose uptake was studied in 3T3-L1 cell line. Meanwhile, in-vivo effect of 28-days treatment with 5mg/kg/day or 20mg/kg/day Rhinacanthin C was studied in streptozotocin-nicotinamide induced male diabetic rats. Following completion of treatment, fasting blood glucose (FBG), HbA1c, insulin and lipid profile levels were measured by biochemical assays. Histopathological changes in pancreas were observed by light microscopy while levels of pancreatic oxidative stress were determined by enzymatic assays. Expression of insulin, TNFα, Ikkβ and cas..View full abstract
Awarded by University of Malaya UMRG research fund
This study was supported by University of Malaya UMRG research fund (RPO11/13HTM).