Journal article

Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study

Aditya Arya, Mazen M Jamil Al-Obaidi, Nayiar Shahid, Mohamed Ibrahim Bin Noordin, Chung Yeng Looi, Won Fen Wong, Si Lay Khaing, Mohd Rais Mustafa

Food and Chemical Toxicology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2014

Abstract

The aim of this study was to investigate the synergistic effects of quercetin (QE) and quinic acid (QA) on a STZ-induced diabetic rat model to determine their potential role in alleviating diabetes and its associated complications. In our study design, diabetic rats were treated with single and combined doses of QE and QA for 45days to analyse their effects on liver, kidney and pancreas tissues. The study result showed that QE and QA treated groups down-regulated hyperglycaemia and oxidative stress by up-regulating insulin and C-peptide levels. Moreover, histological observations of the liver, kidney and pancreas of diabetic rats treated with single and combined doses of QE and QA showed a s..

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University of Melbourne Researchers

Grants

Awarded by University of Malaya research grant


Funding Acknowledgements

This research is financially supported by the University of Malaya research grant; HIR: (H-20001-E00002) and UMRG: RP001D-13BIO & RG360/11HTM. The funding sources were not involved in the study design, collection, analysis, interpretation of data, writing of the report or the decision to submit the article for publication.