Journal article

Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, beta-TC6 and its alleviating role in type 2 diabetic rats

Aditya Arya, Chung Yeng Looi, Shiau Chuen Cheah, Mohd Rais Mustafa, Mustafa Ali Mohd

Journal of Ethnopharmacology | ELSEVIER IRELAND LTD | Published : 2012

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Seeds of Centratherum anthelminticum (Asteraceae) have been popularly used in Ayurvedic medicine to treat diabetes and skin disorders. Folk medicine from Rayalaseema (Andhra Pradesh, India) reported wide spread usage in diabetes. AIM OF THE STUDY: To investigate the hypoglycemic properties and mechanism of the methanolic fraction of C. anthelminticum seeds (CAMFs) on mouse β-TC6 pancreatic cell line and streptozotocin (STZ)-induced diabetic rat models. MATERIALS AND METHODS: We investigated the crude methanolic fraction of C. anthelminticum seeds (CAMFs) on β-TC6 cell line and confirmed its effects on type 1 and type 2 diabetic rats to understand its mechanism..

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University of Melbourne Researchers

Grants

Awarded by IPPP research Grant


Awarded by UM Research Grant


Funding Acknowledgements

This study was supported by an IPPP research Grant (No: PS144/2008C) and by a UM Research Grant (HIR: E00002-20001). The funding sources were not involved in the study design; the collection, analysis, and interpretation of data; the writing of the report; and in the decision to submit the article for publication. The authors sincerely thank Nitika Rai, chief executive of Amritum Bio-Botanica Herbs Research Laboratory Pvt. Ltd., for contributing the plant material.