Journal article

Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don

Soon Huat Tiong, Chung Yeng Looi, Hazrina Hazni, Aditya Arya, Mohammadjavad Paydar, Won Fen Wong, Shiau-Chuen Cheah, Mohd Rais Mustafa, Khalijah Awang

Molecules | MDPI | Published : 2013

Abstract

Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the in vitro antioxidant and antidiabetic activities of the major alkaloids isolated from Catharanthus roseus (L.) G. Don leaves extract. Four alkaloids--vindoline I, vindolidine II, vindolicine III and vindolinine IV--were isolated and identified from the dichloromethane extract (DE) of this plant's leaves. DE and compounds I-III were not cytotoxic towards pancreatic β-TC6 cells at the highest dosage tested (25.0 µg/mL). All four alkaloids induced relatively high glucose uptake in pancreatic β-TC6 or myoblast C2C12 ..

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University of Melbourne Researchers

Grants

Awarded by University of Malaya


Funding Acknowledgements

This work was supported by Post Graduate Research Fund (PS368/2010B), High Impact Research grant (HIR: E00002-20001), UM Research grant (RG041-10BIO) and UM Research Program (RP001/2012A) from University of Malaya. The funding sources were not involved in the study design, collection, analysis, interpretation of data, writing of the report or the decision to submit the article for publication.