Journal article
NATURAL HISTORY OF QUANTITATIVE AUTOFLUORESCENCE IN INTERMEDIATE AGE-RELATED MACULAR DEGENERATION
L Von Der Emde, RH Guymer, M Pfau, E Caruso, P Sivarajah, LAB Hodgson, MB McGuinness, KR Sloan, Z Wu
Retina | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Abstract
Purpose:To investigate differences in quantitative autofluorescence (qAF) imaging measurements between eyes with and without large drusen, and whether qAF measurements change over time in the eyes with large drusen.Methods:Eighty-five eyes from participants with bilateral large drusen and 51 eyes from healthy participants underwent qAF imaging at least once, and the age-related macular degeneration participants were reviewed 6-monthly. Normalized grey values at 9° to 11° eccentricity from the fovea were averaged to provide a summary measure of qAF values (termed qAF8).Results:In a multivariable model, qAF8measurements were not significantly different between age-related macular degeneration ..
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Awarded by Bayer
Funding Acknowledgements
Supported by National Health & Medical Research Council of Australia (project grant no.: APP1027624 [R. H. Guymer], and fellowship grant no.: GNT1103013 (R. H. Guymer), APP1104985 [Z. Wu]), and BUPA Health Foundation (Australia) (R. H. Guymer). CERA receives operational infrastructure support from the Victorian Government. The web-based Research Electronic Data Capture (REDCap) application and open-source platform OpenClinica allowed secure electronic data capture. The study is sponsored by the Centre for Eye Research Australia (CERA), an independent medical research institute and a not-for-profit company.