Macropinocytosis in Different Cell Types: Similarities and Differences
Xiao Peng Lin, Justine D Mintern, Paul A Gleeson
Membranes | MDPI | Published : 2020
Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific internalisation of large amounts of extracellular fluid, solutes and membrane in large endocytic vesicles known as macropinosomes. Macropinocytosis is important in a range of physiological processes, including antigen presentation, nutrient sensing, recycling of plasma proteins, migration and signalling. It has become apparent in recent years from the study of specialised cells that there are multiple pathways of macropinocytosis utilised by different cell types, and some of these pathways are triggered by different stimuli. Understanding the physiological function of macropinocytosis requires knowledge of t..View full abstract
Awarded by Australian Research Council
This research was funded by a Linkage grant from the Australian Research Council (LP106010137).