Acute Administration of Zn, Mg, and Thiamine Improves Postpartum Depression Conditions in Mice
Sara Nikseresht, Sahabeh Etebary, Morteza Karimian, Fatemeh Nabavizadeh, Mohammad Reza Zarrindast, Hamid Reza Sadeghipour
Archives of Iranian Medicine | ACAD MEDICAL SCIENCES I R IRAN | Published : 2012
BACKGROUND: Postpartum depression (PPD) affects approximately half of new mothers. Chronic exposure to progesterone during pregnancy and its withdrawal following delivery increases depression and anxiety. In addition, there are complex interactions between hormones, neurotransmitters, and trace elements. Zinc (Zn) and magnesium (Mg) influence the nervous system by impacting synaptic neurotransmission in the brain. Thiamine (Vit B1) deficiency results in a high percentage of depressive behaviors. Elevated levels of reactive oxygen species in pregnancy are implicated in the pathogenesis of major depression. METHODS: We examined the effects of different combinations of Zn, Mg, and Vit B1 in an ..View full abstract
The authors wish to express their appreciation to Drs. Shadan, Beckley, Dehpour and Zandieh, in addition to Ms. Zaree and Ms. Fatehi for their kind help and Dr Nategh for his cooperation. This study was supported by a grant from Tehran University of Medical Sciences, Tehran, Iran.