Journal article

Acute Administration of Zn, Mg, and Thiamine Improves Postpartum Depression Conditions in Mice

Sara Nikseresht, Sahabeh Etebary, Morteza Karimian, Fatemeh Nabavizadeh, Mohammad Reza Zarrindast, Hamid Reza Sadeghipour

Archives of Iranian Medicine | ACAD MEDICAL SCIENCES I R IRAN | Published : 2012

Abstract

BACKGROUND: Postpartum depression (PPD) affects approximately half of new mothers. Chronic exposure to progesterone during pregnancy and its withdrawal following delivery increases depression and anxiety. In addition, there are complex interactions between hormones, neurotransmitters, and trace elements. Zinc (Zn) and magnesium (Mg) influence the nervous system by impacting synaptic neurotransmission in the brain. Thiamine (Vit B1) deficiency results in a high percentage of depressive behaviors. Elevated levels of reactive oxygen species in pregnancy are implicated in the pathogenesis of major depression. METHODS: We examined the effects of different combinations of Zn, Mg, and Vit B1 in an ..

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