Journal article

Metabolic communication during exercise

Robyn M Murphy, Matthew J Watt, Mark A Febbraio

Nature Metabolism | NATURE RESEARCH | Published : 2020


The coordination of nutrient sensing, delivery, uptake and utilization is essential for maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be achieved only if metabolic information is communicated between the cells and tissues of the entire organism. During intense exercise, the metabolic demand of the body can increase approximately 100-fold. Thus, exercise is a physiological state in which intertissue communication is of paramount importance. In this Review, we discuss the physiological processes governing intertissue communication during exercise and the molecules mediating such cross-talk.

University of Melbourne Researchers


Awarded by National Health & Medical Research Council of Australia

Funding Acknowledgements

M.A.F. is supported by a Senior Principal Research Fellowship (APP1116936) and an Investigator Award (APP1194141) from the National Health & Medical Research Council of Australia.