Journal article

Exercise as a protective mechanism against the negative effects of oxidative stress in first-episode psychosis: a biomarker-led study

Emily Fisher, Stephen J Wood, Richard J Elsworthy, Rachel Upthegrove, Sarah Aldred

Translational Psychiatry | SPRINGERNATURE | Published : 2020

Abstract

First-episode psychosis (FEP) is a psychiatric disorder, characterised by positive and negative symptoms, usually emerging during adolescence and early adulthood. FEP represents an early intervention opportunity for intervention in psychosis. Redox disturbance and subsequent oxidative stress have been linked to the pathophysiology of FEP. Exercise training can perturb oxidative stress and rebalance the antioxidant system and thus represents an intervention with the potential to interact with a mechanism of disease. The aim of this study was to assess the effect of exercise on markers of redox status in FEP. Twenty-two young men were recruited from Birmingham Early Intervention services and r..

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University of Melbourne Researchers