The Penicillin Allergy Delabeling Program: A Multicenter Whole-of-Hospital Health Services Intervention and Comparative Effectiveness Study
Kyra YL Chua, Sara Vogrin, Susan Bury, Abby Douglas, Natasha E Holmes, Nixon Tan, Natasha K Brusco, Rebecca Hall, Belinda Lambros, Jacinta Lean, Wendy Stevenson, Misha Devchand, Kent Garrett, Karin Thursky, M Lindsay Grayson, Monica A Slavin, Elizabeth J Phillips, Jason A Trubiano
CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2021
BACKGROUND: Penicillin allergies are associated with inferior patient and antimicrobial stewardship outcomes. We implemented a whole-of-hospital program to assess the efficacy of inpatient delabeling for low-risk penicillin allergies in hospitalized inpatients. METHODS: Patients ≥ 18 years of age with a low-risk penicillin allergy were offered a single-dose oral penicillin challenge or direct label removal based on history (direct delabeling). The primary endpoint was the proportion of patients delabeled. Key secondary endpoints were antibiotic utilization pre- (index admission) and post-delabeling (index admission and 90 days). RESULTS: Between 21 January 2019 and 31 August 2019, we assesse..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) Early Career Research Grant
Awarded by National Institutes of Health
This work was supported by the Better Care Victoria Innovation Fund, Better Care Victoria, Victoria Department of Health, Australia. J. A. T. is supported by a National Health and Medical Research Council (NHMRC) Early Career Research Grant (GNT 1139902), Royal Australasian College of Physicians (RACP) Research Establishment Fellowship and postdoctoral scholarship from the National Centre for Infections in Cancer (NCIC). E. J. P. receives funding from the National Institutes of Health (grants 1P50GM115305-01, R21AI139021, R34AI136815, and 1 R01 HG010863-01) and the National Health and Medical Research Council of Australia.