Journal article

Optimising treatments for sexually transmitted infections: surveillance, pharmacokinetics and pharmacodynamics, and molecular resistance

Arlene C Sena, Laura Bachmann, Christine Johnston, Teodora Wi, Kimberly Workowski, Edward W Hook, Jane S Hocking, George Drusano, Magnus Unemo

The Lancet Infectious Diseases | ELSEVIER SCI LTD | Published : 2020

Abstract

Progressive antimicrobial resistance in Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis has created a pressing need for treatment optimisations for sexually transmitted infections (STIs). In this Review, we aim to highlight urgent needs in global STI management, including: (1) improved surveillance to monitor antimicrobial resistance and clinical outcomes; (2) systematic pharmacokinetic and pharmacodynamic evaluations to ensure resistance suppression and bacterial eradication at all sites of infection; (3) development of novel, affordable antimicrobials; and (4) advancements in new molecular and point-of-care tests to detect antimicrobial resistance determinants. Anti..

View full abstract

Grants

Awarded by US National Institute of Health's (NIH's) Division of Microbiology and Infectious Diseases of the National Institute of Allergy and Infectious Diseases


Funding Acknowledgements

This work was supported by US National Institute of Health's (NIH's) Division of Microbiology and Infectious Diseases of the National Institute of Allergy and Infectious Diseases (contract HHSN272201300012). We thank Carolyn Deal and Peter Wolff at the NIH/NIAID Division of Microbiology and Infectious Diseases; Linda McNeil, Mary Briggs, and other staff at FHI360; the University of Alabama at Birmingham STI-Clinical Trials Group (STI CTG) Executive and Scientific Review Committee members; and the other NIH Technical Consultation speakers and meeting attendees. We would also like to acknowledge Fabian Kong from University of Melbourne for his pharmacological input. The findings and conclusions in this report are our own and do not necessarily represent the official positions of the US Centers for Disease Control and Prevention and WHO.