Journal article

Toward integrative 'omics of the barber's pole worm and related parasitic nematodes

Guangxu Ma, Robin B Gasser, Tao Wang, Pasi K Korhonen, Neil D Young

INFECTION GENETICS AND EVOLUTION | ELSEVIER | Published : 2020

Abstract

Advances in nucleic acid sequencing, mass spectrometry and computational biology have facilitated the identification, annotation and analysis of genes, transcripts, proteins and metabolites in model nematodes (Caenorhabditis elegans and Pristionchus pacificus) and socioeconomically important parasitic nematodes (Clades I, III, IV and V). Significant progress has been made in genomics and transcriptomics as well as in the proteomics and lipidomics of Haemonchus contortus (the barber's pole worm) - one of the most pathogenic representatives of the order Strongylida. Here, we review salient aspects of genomics, transcriptomics, proteomics, lipidomics, glycomics and functional genomics, and disc..

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Grants

Awarded by ARC


Funding Acknowledgements

Funding from the Australian Research Council (ARC), National Health and Medical Research Council (NHMRC) of Australia, BGI International Pty Ltd and Yourgene Health, Melbourne Water is gratefully acknowledged. N.D.Y. held an NHMRC Career Development Fellowship, and P.K.K. holds an NHMRC Early Career Research Fellowship. Project support was through ARC grants LP180101334 (N.D.Y. and P.K.K.) and LP180101085 (R.B.G.).