Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia
Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
Pregnancy Hypertension | ELSEVIER SCI LTD | Published : 2020
Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance for the obstetrics field. We recently identified esomeprazole and sulfasalazine as potential candidates for the treatment of preeclampsia. Both reduce placental and endothelial secretion of sFlt-1 and sENG and mitigate endothelial dysfunction in vitro. Here we assessed whether esomeprazole and sulfasalazine in combination would additively attenuate the elevated release of anti-angiogenic factors and markers of endothelial dysfunction, key characteristics of preeclampsia. Primary placental tissue and cells, and primary endothelial cells were treated with esomepraz..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
This study was funded by the Norman Beischer Medical Research Foundation and a grant from the National Health and Medical Research Council of Australia (NHMRC #1101871). The NHMRC also provided salary support (TKL; #1159261 FB; #1142636 ST; #1136418 and NJH; #1146128). The funders had no role in study design, data collection, analysis or decision to publish.