Journal article

Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing

Prasath Pararajalingam, Krysta M Coyle, Sarah E Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, Quratulain Qureshi, Bruno M Grande, Christopher Rushton, Graham W Slack, Andrew J Mungall, Constantine S Tam, Rishu Agarwal, Sarah-Jane Dawson, Georg Lenz, Sriram Balasubramanian, Randy D Gascoyne, Christian Steidl, Joseph Connors Show all

Blood | AMER SOC HEMATOLOGY | Published : 2020

Abstract

Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma (NHL) that is incurable with standard therapies. The genetic drivers of this cancer have not been firmly established, and the features that contribute to differences in clinical course remain limited. To extend our understanding of the biological pathways involved in this malignancy, we performed a large-scale genomic analysis of MCL using data from 51 exomes and 34 genomes alongside previously published exome cohorts. To confirm our findings, we resequenced the genes identified in the exome cohort in 191 MCL tumors, each having clinical follow-up data. We confirmed the prognostic association of TP53 and NOTCH1 mutations. ..

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Grants

Awarded by Canadian Institutes of Health Research (CIHR)


Awarded by Terry Fox Research Institute


Funding Acknowledgements

This work was supported by the Canadian Institutes of Health Research (CIHR; 300738) and the Terry Fox Research Institute (1021, 1043, and 1061). Some of the biological materials were provided by the Ontario Tumour Bank, which is supported by the Ontario Institute for Cancer Research through funding provided by the Government of Ontario. K.M.C. is supported by a CIHR postdoctoral fellowship.