Journal article

The TP53 mutation rate differs in breast cancers that arise in women with high or low mammographic density

Dane Cheasley, Lisa Devereux, Siobhan Hughes, Carolyn Nickson, Pietro Procopio, Grant Lee, Na Li, Vicki Pridmore, Kenneth Elder, G Bruce Mann, Tanjina Kader, Simone M Rowley, Stephen B Fox, David Byrne, Hugo Saunders, Kenji M Fujihara, Belle Lim, Kylie L Gorringe, Ian G Campbell

npj Breast Cancer | NATURE RESEARCH | Published : 2020

Abstract

Mammographic density (MD) influences breast cancer risk, but how this is mediated is unknown. Molecular differences between breast cancers arising in the context of the lowest and highest quintiles of mammographic density may identify the mechanism through which MD drives breast cancer development. Women diagnosed with invasive or in situ breast cancer where MD measurement was also available (n = 842) were identified from the Lifepool cohort of >54,000 women participating in population-based mammographic screening. This group included 142 carcinomas in the lowest quintile of MD and 119 carcinomas in the highest quintile. Clinico-pathological and family history information were recorded. Tumo..

View full abstract

Grants

Awarded by Victorian Cancer Agency


Awarded by National Breast Cancer Foundation


Awarded by NHMRC


Awarded by Cancer Australia


Funding Acknowledgements

The authors would like to acknowledge the Bioinformatics and Molecular Genomics Core Facilities of the Peter MacCallum Cancer Centre. This work would not have been possible without financial support by the Victorian Cancer Agency (ECSG15003, to D.C.), the National Breast Cancer Foundation (IF-15-004 & CG-08-02, to I.G.C.), the NHMRC (APP1079329 to S.B.F.), and Cancer Australia (1084963, to I.G.C.). The funders had no role in the design and execution of this study.