Journal article

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

Riley D Metcalfe, Tracy L Putoczki, Michael DW Griffin



Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)-6, the first and prototypical member of the IL-6 family of cytokines, nearly all of which utilize the common signaling receptor, gp130. In the last decade, there have been numerous advances in our understanding of the structural mechanisms of IL-6 family signaling, particularly for IL-6 itself. However, our understanding of the detailed structural mechanisms underlying signaling by most IL-6 family members remains limited. With the emergenc..

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Awarded by National Health & Medical Research Council of Australia

Awarded by Worldwide Cancer Research

Awarded by Victorian Cancer Agency Fellowship

Awarded by Australian Research Council Future Fellowship

Funding Acknowledgements

This work was supported by the National Health & Medical Research Council of Australia (APP1147621 and APP1080498) andWorldwide Cancer Research (14-1197). RMwas the recipient of an Australian Government Research Training Program Scholarship. TP was the recipient of a Victorian Cancer Agency Fellowship (MCRF16009), a Dyson Bequest WEHI Centenary Fellowship, and a Viertel Senior Medical Research Fellowship. MG was the recipient of an Australian Research Council Future Fellowship (project number FT140100544). Funding from the Victorian Government Operational Infrastructure Support Scheme was acknowledged.