Cyclic Hypoxia Exposure Accelerates the Progression of Amoebic Gill Disease
Tina Oldham, Tim Dempster, Philip Crosbie, Mark Adams, Barbara Nowak
Pathogens | MDPI | Published : 2020
Amoebic gill disease (AGD), caused by the amoeba Neoparamoeba perurans, has led to considerable economic losses in every major Atlantic salmon producing country, and is increasing in frequency. The most serious infections occur during summer and autumn, when temperatures are high and poor dissolved oxygen (DO) conditions are most common. Here, we tested if exposure to cyclic hypoxia at DO saturations of 40–60% altered the course of infection with N. perurans compared to normoxic controls maintained at ≥90% DO saturation. Although hypoxia exposure did not increase initial susceptibility to N. perurans, it accelerated progression of the disease. By 7 days post-inoculation, amoeba counts estima..View full abstract
Funding for this work was provided by an Australian Research Council Future Fellowship grant to Tim Dempster and an Australian Government Research Training Program Scholarship awarded to Tina Oldham.