Journal article

Immunometabolism ofLeishmaniagranulomas

Eleanor C Saunders, Malcolm J McConville

Immunology & Cell Biology | WILEY | Published : 2020

Abstract

Leishmania are parasitic protists that cause a spectrum of diseases in humans characterized by the formation of granulomatous lesions in the skin or other tissues, such as liver and spleen. The extent to which Leishmania granulomas constrain or promote parasite growth is critically dependent on the host T-helper type 1/T-helper type 2 immune response and the localized functional polarization of infected and noninfected macrophages toward a classically (M1) or alternatively (M2) activated phenotype. Recent studies have shown that metabolic reprograming of M1 and M2 macrophages underpins the capacity of these cells to act as permissive or nonpermissive host reservoirs, respectively. In this re..

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Grants

Awarded by NHMRC Principal Research Fellowship


Awarded by NHMRC Project Grant


Funding Acknowledgements

We thank Dr Katrina Binger and Ms Erin McGowen for discussions. This work is supported by an NHMRC Principal Research Fellowship (#1154540) and NHMRC Project Grant (#1183085) to MJM.