Journal article

Influence of the MUC1 Cell Surface Mucin on Gastric Mucosal Gene Expression Profiles in Response toHelicobacter pyloriInfection in Mice

Yong H Sheng, Garrett Z Ng, Kim M Summers, Alison L Every, Gareth Price, Sumaira Z Hasnain, Philip Sutton, Michael A McGuckin

Frontiers in Cellular and Infection Microbiology | FRONTIERS MEDIA SA | Published : 2020

Abstract

The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. The aim of this study was to establish the time-course of molecular events in MUC1-modulated gene expression profiles in response to H. pylori infection in wild type (WT) and MUC1-deficient mice using microarray-determined mRNA expression, gene network analysis and Ingenuity Pathway Analysis (IPA). A time-course over the first 72 h of infection showed significantly higher mucosal loads of bacteria at 8 h of infection in Muc1-/- mice compared with WT, confirming its imp..

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