Journal article

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

DS Khoury, P Cao, SG Zaloumis, MP Davenport

Trends in Parasitology | CELL PRESS | Published : 2020

Abstract

Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.

University of Melbourne Researchers