Journal article
Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial
DS Khoury, P Cao, SG Zaloumis, MP Davenport
Trends in Parasitology | CELL PRESS | Published : 2020
Abstract
Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.
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Awarded by Australian Research Council