Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial
David S Khoury, Pengxing Cao, Sophie G Zaloumis, Miles P Davenport
TRENDS IN PARASITOLOGY | ELSEVIER SCI LTD | Published : 2020
Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.