Journal article

Anti-inflammatory effects of phenolic acids punicalagin and curcumin in human placenta and adipose tissue

Caitlyn Nguyen-Ngo, Jane C Willcox, Martha Lappas

Placenta | W B SAUNDERS CO LTD | Published : 2020


INTRODUCTION: The world is witnessing a steady rise in the prevalence of gestational diabetes mellitus (GDM), correlated with the current obesity epidemic. Both GDM and obesity negatively impact both the health of women but also that of the next generation. GDM and maternal obesity are associated with increased maternal and fetal inflammation and oxidative stress. A safe and effective intervention that can prevent these pathological features, and reduce the intergenerational burden, is required. Phenolic acids, such as punicalagin and curcumin, possess anti-inflammatory and antioxidant properties. Thus, the aim of this study was to examine the effects of punicalagin and curcumin on pro-infla..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Associate Professor Martha Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025) and Research Fellowship from the University of Melbourne. Caitlyn Nguyen-Ngo is supported by an Australian Government Research Training Program (RTP) Scholarship. This study was supported by grants from the Norman Beischer Medical Research Foundation, Diabetes Australia, Austin Medical Research Foundation, Rebecca L. Cooper Foundation, and the Department of Obstetrics and Gynaecology (University of Melbourne).