FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
Jae Hong Im, Jon N Buzzelli, Keaton Jones, Fanny Franchini, Alex Gordon-Weeks, Bostjan Markelc, Jianzhou Chen, Jin Kim, Yunhong Cao, Ruth J Muschel
NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2020
Regulation of the programming of tumour-associated macrophages (TAMs) controls tumour growth and anti-tumour immunity. We examined the role of FGF2 in that regulation. Tumours in mice genetically deficient in low-molecular weight FGF2 (FGF2LMW) regress dependent on T cells. Yet, TAMS not T cells express FGF receptors. Bone marrow derived-macrophages from Fgf2LMW-/- mice co-injected with cancer cells reduce tumour growth and express more inflammatory cytokines. FGF2 is induced in the tumour microenvironment following fractionated radiation in murine tumours consistent with clinical reports. Combination treatment of in vivo tumours with fractionated radiation and a blocking antibody to FGF2 pr..View full abstract
Awarded by Cancer Research UK
Funding by Cancer Research UK, C5255/A23755. The authors would like to thank Cary Queen, Galaxy Biotech, Sunnyvale, CA for his interest and help in this work.