Journal article

Common Susceptibility Loci for Male Breast Cancer

Sarah Maguire, Eleni Perraki, Katarzyna Tomczyk, Michael E Jones, Olivia Fletcher, Matthew Pugh, Timothy Winter, Kyle Thompson, Rosie Cooke, Alison Trainer, Paul James, Stig Bojesen, Henrik Flyger, Heli Nevanlinna, Johanna Mattson, Eitan Friedman, Yael Laitman, Domenico Palli, Giovanna Masala, Ines Zanna Show all

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | OXFORD UNIV PRESS INC | Published : 2021

Abstract

BACKGROUND: The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC. METHODS: We performed genome-wide single nucleotide polymorphism genotyping of European ancestry MBC case subjects and controls in 3 stages. Associations between directly genotyped and imputed single nucleotide polymorphisms with MBC were assessed using fixed-effects meta-analysis of 1380 cases and 3620 controls. Replication genotyping of 810 cases and 1026 co..

View full abstract

Grants

Awarded by UK Medical Research Council


Awarded by Wellcome Trust


Awarded by Italian Association for Cancer Research (Fondazione AIRC)


Awarded by Cancer Research UK


Awarded by US ARMY Grant


Awarded by US National Institutes of Health (NIH)


Funding Acknowledgements

This work was supported by Programme Grants from Breast Cancer Now, including Programme Funding to the Breast Cancer Now Toby Robins Research Centre, the Institute of Cancer Research, and by funding from Queen's University Belfast to NO. We acknowledge National Institute for Health Research (NIHR) funding to the Royal Marsden Hospital Biomedical Research Centre (BRC). This work made use of data and samples generated by the 1958 British Birth Cohort under grant G0000934 from the UK Medical Research Council and grant 068545/Z/02 from the Wellcome Trust. The Finnish Male Breast Cancer Study acknowledges funding from the Finnish Breast Cancer Group, the Finnish Oncology Association, and the Salonoja Foundation. LO acknowledges funding from the Italian Association for Cancer Research (Fondazione AIRC IG2018-21389). DP acknowledges funding from the Istituto Toscano Tumori, Florence, Italy. SEARCH is funded by a grant from Cancer Research UK (C490/A10124) and is supported by the University of Cambridge NIHR Biomedical Research Centre. AMD has been funded by Cancer Research UK grant CA8197/A10865 and by the Joseph Mitchell Fund. DTB acknowledges funding by Cancer Research UK (Programme Award C588/A10589). MG-D and JEC acknowledge the support of the Department of Pathology of the CHUS Santiago Hospital, the Galician Foundation of Genomic Medicine, and the Program Grupos Emergentes, Cancer Genetics Unit of CHUVI, Instituto de Salud Carlos III. HO and IH acknowledge funding from the Swedish Cancer Society and The Swedish Medical Research Council. The collection of samples and epidemiological data for the US cases was supported by US ARMY Grant DAMD-17-96-I-6266 and US National Institutes of Health (NIH) grant R01CA74415. SLN was partially supported by the Morris and Horowitz Families Endowed Professorship at the City of Hope. The Genotype-Tissue Expression Project (GTEx) was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by the National Cancer Institute, the National Human Genome Research Institute, the National Heart, Lung and Blood Institute, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke.