Journal article

Neural Correlates of Sleep Recovery following Melatonin Treatment for Pediatric Concussion: A Randomized Controlled Trial

Kartik K Iyer, Andrew Zalesky, Luca Cocchi, Karen M Barlow

JOURNAL OF NEUROTRAUMA | MARY ANN LIEBERT, INC | Published : 2020

Abstract

Evidence-based treatments for children with persistent post-concussion symptoms (PPCS) are few and limited. Common PPCS complaints such as sleep disturbance and fatigue could be ameliorated via the supplementation of melatonin, which has significant neuroprotective and anti-inflammatory properties. This study aims to identify neural correlates of melatonin treatment with changes in sleep disturbances and clinical recovery in a pediatric cohort with PPCS. We examined structural and functional neuroimaging (fMRI) in 62 children with PPCS in a randomized, double-blind, placebo-controlled trial of 3 mg or 10 mg of melatonin (NCT01874847). The primary outcome was the total youth self-report Post-..

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University of Melbourne Researchers

Grants

Awarded by Canadian Institutes of Health Research


Awarded by Australian National Health Medical Research Council


Funding Acknowledgements

K.M.B. acknowledges funding support from the Canadian Institutes of Health Research (grant number: 293375) and Motor Accident Insurance Commission (MAIC, Queensland, Australia). L.C. is supported by the Australian National Health Medical Research Council (L.C. 1099082 and 1138711).