Journal article

Does parental farm upbringing influence the risk of asthma in offspring? A three-generation study

Signe Timm, Cecilie Svanes, Morten Frydenberg, Torben Sigsgaard, Mathias Holm, Christer Janson, Lennart Braback, Brittany Campbell, Marie Kjaer Madsen, Nils Oskar Jogi, Rain Jogi, Linus Schioler, Randi Jacobsen Bertelsen, Ane Johannessen, Jose Luis Sanchez-Ramos, Jesus Martinez-Moretalla, Julia Dratva, Shyamali Dharmage, Vivi Schlunssen



BACKGROUND: A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma. METHODS: Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945-1971, denoted G1), their 9991 parents (G0) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on G0 and G1 from G1 ..

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Awarded by Faculty of Health, Aarhus University, Denmark

Awarded by Wood Dust Foundation

Awarded by Norwegian Research Council

Awarded by HelseVest Norway

Awarded by Estonian Science Foundation

Awarded by Estonian Research Council

Awarded by Sociedad Espanola de Neumologia y Cirugia Toracica Spain

Funding Acknowledgements

The ECRHS/RHINE/RHINESSA study was supported by grants from the Faculty of Health, Aarhus University, Denmark (Project No. 240008), The Wood Dust Foundation (Project No. 444508795), the Danish Lung Association, the Swedish Heart and Lung Foundation, the Swedish Association Against Asthma and Allergy, the Swedish Association against Heart and Lung Disease, the Swedish Council for Working Life and Social Research, the Bror Hjerpstedt Foundation, the Vardal Foundation for Health Care and Allergic Research, the Norwegian Research Council (Grant no. 214123, 230827/F20, 228174 and 135773/330), the Norwegian Asthma and Allergy Association, HelseVest Norway (Grant no. 911 631), the Icelandic Research Council, the University of Iceland Research Fund, the Icelandic GP's Research Fund, the Estonian Science Foundation (Grant No. 4350), the Estonian Research Council (Grant no. PUT562), Melbourne University, National Health & Medical Research Council of Australia, SEPAR Spain, Sociedad Espanola de Neumologia y Cirugia Toracica Spain and Horizon2020 PHC1 (Grant no. 633212). For further information about funding sources, please consult C.S. are members of the COST BM1201 network. S.T. received a PhD scholarship from Aarhus University, Denmark.