End-tidal to Arterial Gradients and Alveolar Deadspace for Anesthetic Agents
Philip J Peyton, Jan Hendrickx, Rene JE Grouls, Andre Van Zundert, Andre De Wolf
ANESTHESIOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
BACKGROUND: According to the "three-compartment" model of ventilation-perfusion ((Equation is included in full-text article.)) inequality, increased (Equation is included in full-text article.)scatter in the lung under general anesthesia is reflected in increased alveolar deadspace fraction (VDA/VA) customarily measured using end-tidal to arterial (A-a) partial pressure gradients for carbon dioxide. A-a gradients for anesthetic agents such as isoflurane are also significant but have been shown to be inconsistent with those for carbon dioxide under the three-compartment theory. The authors hypothesized that three-compartment VDA/VA calculated using partial pressures of four inhalational agent..View full abstract
This work was supported by a project grant from the Australian and New Zealand College of Anaesthetists Research Foundation, Melbourne, Australia, and by an internal research grant of the Catharina Hospital, Eindhoven, The Netherlands, and an internal research grant of the Onze-Lieve-Vrouw (OLV) Hospital, Aalst, Belgium.