Treatment efficacy for pharyngeal Neisseria gonorrhoeae: a systematic review and meta-analysis of randomized controlled trials
Fabian YS Kong, Christina L Hatzis, Andrew Lau, Deborah A Williamson, Eric PF Chow, Christopher K Fairley, Jane S Hocking
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2020
BACKGROUND: Rising gonorrhoea rates require highly effective treatments to reduce transmission and prevent development of antimicrobial resistance. Currently the most effective treatments for pharyngeal gonorrhoea remain unclear. This review aimed to estimate treatment efficacy for pharyngeal gonorrhoea. METHODS: Online bibliographic databases were searched for the period 1 January 2000 to 17 September 2019 for treatments of gonorrhoea. All randomized controlled trials (RCTs) with data on pharyngeal gonorrhoea among participants aged 15 years or above, published in English, were included. Meta-analyses (random effects) were used to estimate the treatment efficacy, defined as microbiological ..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
This study was carried out as part of our routine work for all authors. E.P.F.C., C.K.F. and D.A.W. are supported by an Australian National Health and Medical Research Council (NHMRC) Investigator Grants (GNT1172873, GNT1172900, GNT1174555, respectively), J.S.H. by a NHMRC Senior Research Fellowship (GNT1042907) and F.Y.S.K. by NHMRC Ideas Grant (APP1181057).