Journal article

Intrinsic connectomes underlying response to trauma-focused psychotherapy in post-traumatic stress disorder

Mayuresh S Korgaonkar, Cassandra Chakouch, Isabella A Breukelaar, May Erlinger, Kim L Felmingham, David Forbes, Leanne M Williams, Richard A Bryant

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Although trauma-focused cognitive behavior therapy (TF-CBT) is the frontline treatment for post-traumatic stress disorder (PTSD), up to one-half of patients are treatment nonresponders. To understand treatment nonresponse, it is important to understand the neural mechanisms of TF-CBT. Here, we used whole-brain intrinsic functional connectivity analysis to identify neural connectomic signatures of treatment outcome. In total, 36 PTSD patients and 36 healthy individuals underwent functional MRI at pre-treatment baseline. Patients then underwent nine sessions of TF-CBT and completed clinical and follow-up MRIs. We used an established large-scale brain network atlas to parcellate the brain into ..

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Grants

Awarded by National Health and Medical Research Council Program


Awarded by NHMRC CCRE Grant


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council Program Grant (1073041), NHMRC CCRE Grant (455431), and Centenary of Anzac Centre, Phoenix, Australia, University of Melbourne, Carlton, Australia. The study sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the paper; decision to submit the paper for publication.