Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control

WA Nazni; AA Hoffmann; A Noor Afizah; YL Cheong; MV Mancini; N Golding; MRG Kamarul; AKM Arif; H Thohir; HS Nur Syamimi; MZ Nur Zatil Aqmar; MM Nur Ruqqayah; A Siti Nor Syazwani; A Faiz; MNFR Irfan; S Rubaaini; N Nuradila; MMN Nizam; MS Mohamad Irwan; NM Endersby-Harshman; VL White; TH Ant; C Herd; HA Hasnor; R Abu Bakar; MD Hapsah; K Khadijah; D Kamilan; SC Lee; M Paid; K Fadzilah; BS Gill; HL Lee; SP Sinkins

Journal article

Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control

WA Nazni, AA Hoffmann, A Noor Afizah, YL Cheong, MV Mancini, N Golding, MRG Kamarul, AKM Arif, H Thohir, HS Nur Syamimi, MZ Nur Zatil Aqmar, MM Nur Ruqqayah, A Siti Nor Syazwani, A Faiz, MNFR Irfan, S Rubaaini, N Nuradila, MMN Nizam, MS Mohamad Irwan, NM Endersby-Harshman Show all

Cold Spring Harbor Laboratory | Published : 2019

DOI: 10.1101/775965

Abstract

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti . The w Mel Wolbachia strain has previously been trialed in open releases of Ae. aegypti ; however the w AlbB strain has been shown to maintain higher density than w Mel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying w AlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency..

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