Predicting the Spatial Dynamics ofWolbachiaInfections inAedes AegyptiArbovirus Vector Populations in Heterogeneous Landscapes

Abstract

ABSTRACT A promising strategy for reducing the transmission of dengue and other arboviral human diseases by Aedes aegypti mosquito vector populations involves field introductions of the endosymbiotic bacteria Wolbachia . Wolbachia infections inhibit viral transmission by the mosquito, and can spread between mosquito hosts to reach high frequencies in the vector population. Wolbachia spreads by maternal transmission, and spread dynamics can be variable and highly dependent on natural mosquito population dynamics, population structure and fitness components. We develop a mathematical model of an Ae. aegypti metapopulation that incorporates empirically validated relationships describing densi..