Some new morpholine-based Schiff-base complexes; Synthesis, characterization, anticancer activities and theoretical studies

Abstract

A new morpholine-based ligand (2) has been prepared from condensation of a branched amine containing morpholine, N1-(3-morpholinopropyl)-N1-((pyridine-2-yl)methyl)ethane-1,2-diamine (1), and salicylaldehyde. Metal complexes were synthesized by reaction of the ligand and metal salts in ethanol and the resulting products were characterized by elemental analyses, ESI-MS, 1H and 13C NMR spectra, infrared, and UV–Vis spectroscopy. The structure of two complexes including [ZnL](ClO4) (3) and [NiHL](ClO4)·H2O (6a) have been determined by single crystal X-ray structural analysis, showing that the metal atoms are in a distorted trigonal bipyramidal (Zn) and a square planar (Ni) environment, respectiv..