Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium
Andre Mu, Glen P Carter, Lucy Li, Nicole S Isles, Alison F Vrbanac, James T Morton, Alan K Jarmusch, David P De Souza, Vinod K Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J McConville, Rob Knight, Benjamin P Howden, Timothy P Stinear
mSystems | AMER SOC MICROBIOLOGY | Published : 2020
Vancomycin-resistant Enterococcus faecium (VREfm) is an emerging antibiotic-resistant pathogen. Strain-level investigations are beginning to reveal the molecular mechanisms used by VREfm to colonize regions of the human bowel. However, the role of commensal bacteria during VREfm colonization, in particular following antibiotic treatment, remains largely unknown. We employed amplicon 16S rRNA gene sequencing and metabolomics in a murine model system to try and investigate functional roles of the gut microbiome during VREfm colonization. First-order taxonomic shifts between Bacteroidetes and Tenericutes within the gut microbial community composition were detected both in response to pretreatme..View full abstract
Related Projects (2)
Awarded by Endeavor Research Fellowship (Australia Awards) for collaborative research in the Department of Pediatrics at UCSD, CA, USA
Awarded by National Medical Research Council of Australia
The project was supported by an Endeavor Research Fellowship (Australia Awards) for collaborative research in the Department of Pediatrics at UCSD, CA, USA (ERF PDR 6735_2018) (A.M.). The project was also supported by the National Medical Research Council of Australia, GNT1105525 (T.P.S.) and GNT 1026656 (B.P.H.).