Journal article
Physical activity and lung function-cause or consequence?
A Bédard, AE Carsin, E Fuertes, S Accordini, SC Dharmage, V Garcia-Larsen, J Heinrich, C Janson, A Johannessen, B Leynaert, JL Sánchez-Ramos, GP Peralta, I Pin, G Squillacioti, J Weyler, D Jarvis, J Garcia-Aymerich
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2020
Open access
Abstract
Concerns exist that the positive association of physical activity with better lung function, which has been suggested in previous longitudinal studies in smokers, is due to reverse causation. To investigate this, we applied structural equation modeling (SEM), an exploratory approach, and marginal structural modeling (MSM), an approach from the causal inference framework that corrects for reverse causation and time-dependent confounding and estimates causal effects, on data from participants in the European Community Respiratory Health Survey (ECRHS, a multicentre European cohort study initiated in 1991-1993 with ECRHS I, and with two follow-ups: ECRHS II in 1999-2003, and ECRHS III in 2010-2..
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Awarded by Horizon 2020
Funding Acknowledgements
The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement no 633212. The local investigators and funding agencies for the European Community Respiratory Health Survey (ECRHS II and ECRHS III) did not have any role in the study design, in the data collection, analysis and interpretation, in the writing of the report and in the decision to submit the paper for publication. ISGlobal is a member of CERCA Programme, Generalitat de Catalunya.